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From the Sunday Times:

Though many women with small breasts obsess about being unattractive, women with heavy, cumbrous breasts will testify that the same is true at the other end of the spectrum as they suffer from marked physical discomfort, poor self esteem and other psycho-social related problems. Dr. Purnima Aiyer, Consultant Plastic Surgeon explains the condition known as macromastia.

Macromastia can have a profound effect on a woman's personality and lifestyle. "Many women come to me before they get married," says Dr. Aiyer. "They are so embarrassed - they cannot buy proper clothing, they are often teased by young boys..." Such situations create self-esteem issues, and a woman with macromastia may consider herself utterly unattractive, feel constantly compelled to cover up and draw as little attention as possible to herself. These insecurities may be carried into the workplace.