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From aad.org, a report on dermatology and exercise:

The changing of the season brings cooler weather, shorter days and more people heading to health clubs for a healthy dose of indoor exercise. While experts agree that exercise is one of the most beneficial activities a person can do to improve one's overall health, dermatologists want gym goers to be aware of the hidden dangers of exercise - bothersome skin conditions that can be painful and inhibit further physical activity if left untreated.

Blisters form when friction between an area of the body and athletic equipment causes a splitting of the top layer of skin, allowing fluid build-up.

Runners and those who routinely lift weights often develop blisters. Dr. Adams suggests that the key to preventing blisters is to reduce friction by creating more distance from the equipment to the skin. “Wearing moisture-wicking socks, applying a thin layer of petroleum jelly between the sock and the shoe, and using gloves to lift weights can help prevent blisters from forming,” said Dr. Adams. “Also, there is no better dressing for blisters than your own skin, so you should not peel off the top layer of a blister. If it comes off, keep the blister covered with petroleum jelly and a bandage.”