With her husband Walter F. Parks, Laurie MacDonald runs Dreamworks motion picture division.

MacDonald began her producing career as a documentary and news producer for KRON, the NBC affiliate in San Francisco. She later joined Columbia Pictures, where she served as a vice president of production for five years. In 1994, she joined Amblin Entertainment, where she executive produced How To Make An American Quilt, Trigger Effect, and Twister. MacDonald is the co-head, with Walter Parkes, of DreamWorks Pictures, the motion picture division of DreamWorks SKG.

MacDonald produced Barry Sonnenfeld's blockbuster comedy Men In Black, the most successful film of 1997.